Development and Diversity of Astrocytes

Authors

• Michael R Williamson
• Sanjana Murali
• Benjamin Deneen

Language

English

Publication Date

7-1-2025

Journal

Development

PMID

40626640

PMCID

PMC12276804

PubMedCentral® Posted Date

7-8-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Proper development of the central nervous system (CNS) depends on astrocytes, which are the most abundant glial cells in the CNS. Here, we provide an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate astrocyte development. In addition, we describe the roles of astrocytes in regulating the development of other CNS cell types, with emphasis on neural circuits and vascular networks. We also discuss evidence for astrocyte diversity and its implications for CNS development. Finally, we pose open questions related to astrocyte development and its intersection with astrocyte diversity.

Keywords

Astrocytes, Animals, Humans, Central Nervous System, Cell Differentiation, Astrocyte, CNS development, Cell diversity

Published Open-Access

yes

Recommended Citation

Michael R Williamson, Sanjana Murali, and Benjamin Deneen, "Development and Diversity of Astrocytes" (2025). Faculty, Staff and Students Publications. 7304.
https://digitalcommons.library.tmc.edu/baylor_docs/7304