Language

English

Publication Date

9-1-2025

Journal

Circulation: Cardiovascular Imaging

DOI

10.1161/CIRCIMAGING.124.017420

PMID

40181776

PMCID

PMC12353833

PubMedCentral® Posted Date

4-4-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Background: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of patients with Multisystem Inflammatory Syndrome in Children.

Methods: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement.

Results: A total of 263 CMRs from 255 patients with Multisystem Inflammatory Syndrome in Children were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR.

Conclusions: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed patients with Multisystem Inflammatory Syndrome in Children, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.

Keywords

Humans, Systemic Inflammatory Response Syndrome, Female, Male, Child, Adolescent, Magnetic Resonance Imaging, Cine, COVID-19, Time Factors, Ventricular Dysfunction, Left, North America, Ventricular Function, Left, Child, Preschool

Comments

Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05287412.

Published Open-Access

yes

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