Language
English
Publication Date
1-1-2024
Journal
Frontiers in Microbiomes
DOI
10.3389/frmbi.2024.1456642
PMID
40969174
PMCID
PMC12443060
PubMedCentral® Posted Date
12-3-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Type 2 diabetes (T2D) is a common forerunner of neurodegeneration and accompanying dementia, including Alzheimer's Disease (AD), yet the mechanisms underlying this comorbidity remain unresolved. Individuals of Mexican descent living in South Texas have increased prevalence of comorbid T2D and early onset AD, despite low incidence of the APOE-ε4 risk variant among the population and an absence of a similar predisposition among relatives residing in Mexico - suggesting a role for environmental factors in coincident T2D and AD susceptibility. We therefore sought to test if differences in gut community structure could be observed in this population prior to any AD diagnosis. Here, in a small clinical trial (ClinicalTrials.gov Identifier NCT04602650), we report evidence for altered gut microbial ecology among subjects of Mexican descent living in South Texas with T2D (sT2D) compared to healthy controls without T2D (HC), despite no differences in expressed dietary preferences. We performed metataxonomic 16S rRNA gene amplicon sequencing of study participant stool samples. Although no significant decrease in microbial alpha diversity was observed between sT2D gut communities
Keywords
type 2 diabetes, dementia, neurodegeneration, Alzheimer’s disease, comorbidity, Mexican American, microbiome, western diet
Published Open-Access
yes
Recommended Citation
Matz, Lisa M; Shah, Nisarg S; Porterfield, Laura; et al., "Gut Pathobiont Enrichment Observed in a Population Predisposed to Dementia, Type 2 Diabetics of Mexican Descent Living in South Texas" (2024). Faculty, Staff and Students Publications. 7373.
https://digitalcommons.library.tmc.edu/baylor_docs/7373