Language
English
Publication Date
1-1-2026
Journal
Frontiers in Endocrinology
DOI
10.3389/fendo.2026.1729898
PMID
41821735
PMCID
PMC12975423
PubMedCentral® Posted Date
2-25-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Fetuses with fetal growth restriction (FGR) and selective FGR (sFGR) face elevated health risks both before and after birth. Although the underlying pathomechanisms remain unclear, placental dysfunction is recognized as a major contributing factor. By integrating untargeted transcriptomic data from FGR/sFGR placentae, this study identified 69 differentially expressed mRNAs (DEmRs) and eight differentially expressed miRNAs (DEmiRs). Functional enrichment analysis demonstrated significant enrichment in the angiogenesis and vasculogenesis pathways, with the hypoxia-related genes
Keywords
Humans, Fetal Growth Retardation, Female, Pregnancy, Placenta, Hypoxia, Angiogenesis, Vascular Endothelial Growth Factor A, Neovascularization, Pathologic, Hypoxia-Inducible Factor 1, alpha Subunit, Gene Regulatory Networks, MicroRNAs, Neovascularization, Physiologic, angiogenesis, fetal growth restriction, hypoxia, placentae, transcriptome, vasculogenesis
Published Open-Access
yes
Recommended Citation
Li, Wei; Bai, Xiaoyi; Chan, Oi Ka; et al., "Common and Recurrent Dysregulated Molecular Network of Placental Hypoxia and Associated Vasculogenesis and Angiogenesis in Fetal Growth Restriction" (2026). Faculty, Staff and Students Publications. 7406.
https://digitalcommons.library.tmc.edu/baylor_docs/7406