Language
English
Publication Date
1-1-2026
Journal
Case Reports in Pathology
DOI
10.1155/crip/6767219
PMID
42199998
PMCID
PMC13199989
PubMedCentral® Posted Date
5-25-2026
PubMedCentral® Full Text Version
Post-print
Abstract
The co-occurrence of T-lymphoblastic leukemia/lymphoma and thymic neoplasia is a rare event that can present a diagnostic challenge. In this case report, we describe a 31-year-old man who was found to have thymic neuroendocrine carcinoma and T-lymphoblastic leukemia/lymphoma 2 years after initial treatment for T-lymphoblastic leukemia/lymphoma. The thymic neuroendocrine carcinoma was initially detected in a malignant pleural effusion, and a retrospective review of a preceding lung biopsy suggested the involvement of both tumors within one tissue sample. Immunohistochemical analysis was imperative in highlighting these two elements because despite their unique cytomorphological characteristics, a limited amount of each component was seen in the tissue biopsy. Ancillary testing is critical to the recognition of these entities in small biopsies.
Keywords
immunohistochemistry, neuroendocrine carcinoma, thymic carcinoma, thymus, T-lymphoblastic leukemia/lymphoma
Published Open-Access
yes
Recommended Citation
Oliveira, Kristen; Doan, Mary; Pei, Ying; et al., "Challenges in the Diagnosis of Concurrent T-Lymphoblastic Leukemia/Lymphoma and Thymic Neuroendocrine Carcinoma: A Case Report" (2026). Faculty, Staff and Students Publications. 7485.
https://digitalcommons.library.tmc.edu/baylor_docs/7485