Language
English
Publication Date
6-30-2026
Journal
Head and Neck Pathology
DOI
10.1007/s12105-026-01947-7
PMID
42377805
PMCID
PMC13319295
PubMedCentral® Posted Date
6-30-2026
PubMedCentral® Full Text Version
Post-print
Abstract
Sinonasal squamous cell carcinoma (SNSCC) comprises a heterogeneous group of tumors with emerging molecular subtypes. Human papillomavirus (HPV)-associated SNSCC is a distinct entity, although actionable genomic alterations beyond HPV-driven pathways remain underexplored. Distinguishing HPV-associated SNSCC from carcinoma ex inverted papilloma can be particularly challenging in limited biopsy specimens, as these lesions may appear morphologically similar. We report a case of HPV-associated SNSCC with concurrent FGFR3::TACC3 fusion and NOTCH1 p.C1416 stop-gain mutation.
Keywords
Humans, Receptor, Notch1, Receptor, Fibroblast Growth Factor, Type 3, Papillomavirus Infections, Microtubule-Associated Proteins, Carcinoma, Squamous Cell, Squamous Cell Carcinoma of Head and Neck, Paranasal Sinus Neoplasms, Oncogene Proteins, Fusion, HPV-associated squamous cell carcinoma, FGFR3:TACC3, NOTCH1, Sinonasal tract
Published Open-Access
yes
Recommended Citation
Cao, Xu; Yu, Hong; Soliman, Reham Hamdy Abdulazim; et al., "FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy" (2026). Faculty, Staff and Students Publications. 7486.
https://digitalcommons.library.tmc.edu/baylor_docs/7486