Language

English

Publication Date

1-1-2026

Journal

Annual Review of Medicine

DOI

10.1146/annurev-med-050224-121037

PMID

41592928

Abstract

Peanut allergy is a significant rising public health problem affecting both children and adults. Early peanut introduction has been adopted in multiple westernized nations as a preventative strategic measure to reduce the risk of developing peanut allergy, although implementation faces barriers. Multiple therapies to treat peanut allergy have been developed, including oral immunotherapy and omalizumab as approved treatments to provide protection against reactions from accidental exposure and reduce the risk of anaphylaxis, offering options beyond strict avoidance. Strategies in the developmental pipeline include epicutaneous immunotherapy and sublingual immunotherapy. The future is bright for individuals with peanut allergy, as these breakthroughs can help address the fear, uncertainty, severity, and lack of protection that has become synonymous with this disease. Shared decision-making is needed to ensure that each patient receives the management approach best suited to their needs, preferences, and goals.

Keywords

Humans, Peanut Hypersensitivity, Desensitization, Immunologic, Anaphylaxis, Omalizumab, Arachis, Anti-Allergic Agents, anaphylaxis, anti-IgE, epicutaneous immunotherapy, omalizumab, oral immunotherapy, peanut allergy, sublingual immunotherapy

Published Open-Access

yes

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