Language
English
Publication Date
8-1-2021
Journal
Circulation: Genomic and Precision Medicine
DOI
10.1161/CIRCGEN.120.003288
PMID
34270325
PMCID
PMC8373451
PubMedCentral® Posted Date
7-16-2021
PubMedCentral® Full Text Version
Post-print
Abstract
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the
METHODS: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near
RESULTS: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele;
CONCLUSIONS: Our results identified genetic variants in the
Keywords
Adult, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cholesterol, HDL, Female, Humans, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Sugar-Sweetened Beverages, Triglycerides, carbohydrates, dyslipidemia, epidemiology, genetics, nutrition, sugars, triglyceride
Published Open-Access
yes
Recommended Citation
Haslam, Danielle E; Peloso, Gina M; Guirette, Melanie; et al., "Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations" (2021). Faculty and Staff Publications. 793.
https://digitalcommons.library.tmc.edu/baylor_docs/793
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Dietetics and Clinical Nutrition Commons, Epidemiology Commons, Medical Sciences Commons, Medical Specialties Commons