Language
English
Publication Date
6-27-2025
Journal
bioRxiv
DOI
10.1101/2025.06.25.661524
PMID
40667190
PMCID
PMC12262363
PubMedCentral® Posted Date
6-27-2025
PubMedCentral® Full Text Version
Pre-Print
Abstract
Clinical studies of T cells engineered with chimeric antigen receptor (CAR) targeting CD19 in B-cell malignancies have demonstrated that relapse due to target antigen (CD19) loss or limited CAR T cell persistence is a common occurrence. The possibility of such events is greater in solid tumors, which typically display more heterogeneous antigen expression patterns and are known to directly suppress effector cell proliferation and persistence. T cell engineering strategies to overcome these barriers are being explored. However, strategies to simultaneously address both antigen heterogeneity and T cell longevity, while localizing anti-tumor effects at disease sites, remain limited. In this study we explore a dual antigen targeting strategy by directing independent CARs against the solid tumor targets PSCA and MUC1. To enhance functional persistence in a tumor-localized manner, we expressed the transgenic IL-7 cytokine and receptor (IL-7Rα) in respective CAR products. We now demonstrate the potency and durable antitumor effects of this binary strategy in a pancreatic tumor model.
Keywords
Chimeric antigen receptor, T-cell therapy, IL-7, IL-7R, Solid tumor
Published Open-Access
yes
Recommended Citation
Chavez, Alejandro G Torres; McKenna, Mary K; Gupta, Anmol; et al., "Il-7 Armed Binary Car T Cell Strategy To Augment Potency Against Solid Tumors" (2025). Faculty, Staff and Students Publications. 8115.
https://digitalcommons.library.tmc.edu/baylor_docs/8115