Publication Date

6-1-2021

Journal

Thoroax

DOI

10.1136/thoraxjnl-2020-216244

PMID

33483364

PMCID

PMC8238310

PubMedCentral® Posted Date

6-1-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Aged, Female, Follow-Up Studies, Genetic Testing, Humans, Male, Mass Screening, Middle Aged, Pedigree, Pulmonary Fibrosis, Retrospective Studies, Surveys and Questionnaires, Time Factors, pulmonary fibrosis, MUC5B, decisional regret, genetic counseling, telomere length

Abstract

Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated measures after participants received their results: the Decisional Regret Scale and the Feelings About genomiC Testing Results Questionnaire. More than 90% of relatives reported either no or mild decisional regret. Increased measures of decisional regret and negative feelings were present in those found to have a low diffusion capacity of carbon monoxide or interstitial lung abnormalities. Results of telomere length and genetic testing did not significantly impact regret.

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