Publication Date
6-1-2021
Journal
Thoroax
DOI
10.1136/thoraxjnl-2020-216244
PMID
33483364
PMCID
PMC8238310
PubMedCentral® Posted Date
6-1-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Aged, Female, Follow-Up Studies, Genetic Testing, Humans, Male, Mass Screening, Middle Aged, Pedigree, Pulmonary Fibrosis, Retrospective Studies, Surveys and Questionnaires, Time Factors, pulmonary fibrosis, MUC5B, decisional regret, genetic counseling, telomere length
Abstract
Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated measures after participants received their results: the Decisional Regret Scale and the Feelings About genomiC Testing Results Questionnaire. More than 90% of relatives reported either no or mild decisional regret. Increased measures of decisional regret and negative feelings were present in those found to have a low diffusion capacity of carbon monoxide or interstitial lung abnormalities. Results of telomere length and genetic testing did not significantly impact regret.
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Biochemistry, Biophysics, and Structural Biology Commons, Biology Commons, Medical Sciences Commons, Medical Specialties Commons
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