Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group

Authors

• Suzanne P MacFarland
• Kerri Becktell
• Kami Wolfe Schneider
• Roland P Kuiper
• Harry Lesmana
• Julia Meade
• Kim E Nichols
• Christopher C Porter
• Sharon A Savage
• Kris Ann Schultz
• Hamish Scott
• Lisa States
• Uri Tabori
• Chieko Tamura
• Gail Tomlinson
• Kristin Zelley
• Carol Durno
• Andrew Bauer
• Sharon E Plon

Language

English

Publication Date

10-15-2024

Journal

Clinical Cancer Research

DOI

10.1158/1078-0432.CCR-24-0953

PMID

39190470

PMCID

PMC12826535

PubMedCentral® Posted Date

1-23-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Gastrointestinal (GI) polyposis and cancer in pediatric patients is frequently due to an underlying hereditary cancer risk syndrome requiring ongoing cancer screening. Identification of at-risk patients through family history, clinical features of a syndrome, or symptom onset ensures appropriate cancer risk assessment and management in childhood and beyond. In this 2024 perspective, we outline updates to the hereditary GI cancer screening guidelines first published by the American Association of Cancer Research Pediatric Cancer Predisposition Workshop in 2017. These guidelines consider existing recommendations by pediatric and adult gastroenterology consortia to ensure alignment with gastroenterology practices in managing polyposis conditions. We specifically address the recommendations for pediatric screening in familial adenomatous polyposis, Peutz-Jeghers syndrome, and juvenile polyposis syndrome. Further, we emphasize the importance of multidisciplinary care and partnership with gastroenterology, as it is crucial in management of children and families with these conditions.

Keywords

Child, Humans, Adenomatous Polyposis Coli, Early Detection of Cancer, Gastrointestinal Neoplasms, Genetic Predisposition to Disease, Genetic Testing, Neoplastic Syndromes, Hereditary, Peutz-Jeghers Syndrome, Practice Guidelines as Topic, Risk Assessment, polyposis, familial adenomatous polyposis, juvenile polyposis syndrome, Peutz-Jeghers syndrome

Published Open-Access

yes

Recommended Citation

MacFarland, Suzanne P; Becktell, Kerri; Schneider, Kami Wolfe; et al., "Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group" (2024). Faculty, Staff and Students Publications. 8215.
https://digitalcommons.library.tmc.edu/baylor_docs/8215