Publication Date

2-1-2021

Journal

The American Journal of Cardiology

DOI

10.1016/j.amjcard.2020.10.049

PMID

33144163

PMCID

PMC8210786

PubMedCentral® Posted Date

2-1-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Aged, Ankle Brachial Index, Blood Flow Velocity, Exercise Test, Female, Humans, Leg, Magnetic Resonance Imaging, Male, Peripheral Arterial Disease, Regional Blood Flow, Retrospective Studies, Walking, peripheral artery disease, magnetic resonance imaging, arterial signal enhancement, cross-sectional leg muscle area, peak walking time

Abstract

Peripheral artery disease (PAD) is associated with impaired lower extremity function. We hypothesized that contrast-enhanced magnetic resonance imaging (CE-MRI) based arterial signal enhancement (SE) measures are associated with markers of PAD. A total of 66 participants were enrolled, 10 were excluded due to incomplete data, resulting in 56 participants for the final analyses (36 PAD, 20 matched controls). MR imaging was performed postreactive hyperemia using bilateral thigh blood-pressure cuffs. First pass-perfusion images were acquired at the mid-calf region with a high-resolution saturation recovery gradient echo pulse sequence, and arterial SE was measured for the lower extremity arteries. As expected, peak walking time (PWT) was reduced in PAD patients compared with controls (282 [248 to 317] sec, vs 353 [346 to 360] sec; p = 0.002), and postexercise ankle brachial index (ABI) decreased in PAD patients but not in controls (PAD: 0.75 ± 0.2, 0.60 [0.5 to 0.7]; p

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