Publication Date
1-1-2021
Journal
Baylor University Medical Center Proceedings
DOI
10.1080/08998280.2021.1953884
PMID
34733005
PMCID
PMC8545139
PubMedCentral® Posted Date
8-18-2021
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Crazy paving, ECMO, PAP, pulmonary alveolar proteinosis, whole-lung lavage
Abstract
Pulmonary alveolar proteinosis is an uncommon cause of insidious onset shortness of breath and hypoxemia. It is caused by an accumulation of surfactant within the alveoli. Left untreated, it can be fatal. Standard-of-care treatment is whole-lung lavage; however, in severe cases, the associated hypoxemia can be profound and single-lung ventilation would not be tolerated, potentially preventing a lifesaving treatment. Single cases using veno-venous extracorporeal membrane oxygenation to perform whole-lung lavage have been reported. Here we describe three patients with severe pulmonary alveolar proteinosis who were successfully treated with whole-lung lavage using veno-venous extracorporeal membrane oxygenation for oxygenation support.
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Biochemistry, Biophysics, and Structural Biology Commons, Internal Medicine Commons, Medical Sciences Commons, Pulmonology Commons, Respiratory Tract Diseases Commons