Publication Date

7-1-2022

Journal

Indian Journal of Thoracic and Cardiovascular Surgery

DOI

10.1007/s12055-021-01228-8

PMID

35756955

PMCID

PMC9226251

PubMedCentral® Posted Date

11-16-2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Chronic rejection, Chronic lung allograft dysfunction, Lung transplantation

Abstract

Lung transplantation remains the only cure for selected patients with advanced irreversible lung diseases. More than 4000 lung transplants are performed worldwide annually. In the last two decades, significant advances have been made in this arena, the most impactful being a modest but improved survival of the recipients. Unfortunately majority of recipients still succumb to chronic lung allograft dysfunction (CLAD), and it remains the most common cause of death after the first year of transplantation. Below is a concise review of the current definition of CLAD, including the various phenotypes, and a brief discussion of the tools available for its diagnosis and management.

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