Publication Date
7-1-2022
Journal
Indian Journal of Thoracic and Cardiovascular Surgery
DOI
10.1007/s12055-021-01228-8
PMID
35756955
PMCID
PMC9226251
PubMedCentral® Posted Date
11-16-2021
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Chronic rejection, Chronic lung allograft dysfunction, Lung transplantation
Abstract
Lung transplantation remains the only cure for selected patients with advanced irreversible lung diseases. More than 4000 lung transplants are performed worldwide annually. In the last two decades, significant advances have been made in this arena, the most impactful being a modest but improved survival of the recipients. Unfortunately majority of recipients still succumb to chronic lung allograft dysfunction (CLAD), and it remains the most common cause of death after the first year of transplantation. Below is a concise review of the current definition of CLAD, including the various phenotypes, and a brief discussion of the tools available for its diagnosis and management.
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