Language

English

Publication Date

2-1-2020

Journal

International Journal of Cardiology

DOI

10.1016/j.ijcard.2019.09.016

PMID

31611091

PMCID

PMC7924730

PubMedCentral® Posted Date

3-2-2021

PubMedCentral® Full Text Version

Author MSS

Abstract

BACKGROUND: Randomized clinical trials demonstrated the benefits of percutaneous coronary interventions (PCI) in diverse clinical settings. Patients with cancer were not routinely included in these studies.

METHODS/RESULTS: Literature search of PubMed, Cochrane, Medline, SCOPUS, EMBASE, and ClinicalTrials was conducted to identify studies that assessed one-year all-cause, cardiovascular and non-cardiovascular mortality in patients with historical or active cancer. Using the random effects model, we computed risk ratios (RRs) and standardized mean differences and their 95% confidence intervals for the dichotomous and continuous measures and outcomes, respectively. Of 171 articles evaluated in total, 5 eligible studies were included in this meta-analysis. In total, 33,175 patients receiving PCI were analyzed, of whom 3323 patients had cancer and 29,852 no cancer history. Patients in the cancer group had greater all-cause mortality [RR 2.22 (1.51-3.26; p

CONCLUSIONS: Patients with cancer undergoing PCI have worse mid-term outcomes compared to non-cancer patients. Cancer patients should be managed by a multi-specialist team, in an effort to close the mortality gap.

Keywords

Cardiovascular Diseases, Humans, Mortality, Myocardial Infarction, Neoplasms, Percutaneous Coronary Intervention, Randomized Controlled Trials as Topic, Treatment Outcome, Cancer, Percutaneous coronary intervention, Mortality, Outcomes, Drug eluding stent, Meta-analysis

Published Open-Access

yes

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