Language
English
Publication Date
9-1-2021
Journal
Annals of Cardiothoracic Surgery
DOI
10.21037/acs-2021-tviv-28
PMID
34733693
PMCID
PMC8505928
PubMedCentral® Posted Date
9-10-2021
PubMedCentral® Full Text Version
Post-print
Abstract
BACKGROUND: Transcatheter pulmonary valve replacement (TPVR) is now an established modality for pulmonary valve replacement in suitable candidates. We aim to describe our experience with TPVR in adults.
METHODS: This is a descriptive study of all TPVR performed in adults with congenital heart disease at a single institution from 2010-2020. All adult patients (defined as 18 years old or older at TPVR) were included. Time-to-event outcomes were described using Kaplan-Meier estimates with 95% confidence intervals (CIs).
RESULTS: Out of a total of 200 patients that had undergone TPVR, 81 patients (57% male) met the inclusion criteria, with a median age and weight of 26 years (IQR 21-37) and 71.0 kg (IQR 54.6-89.0), respectively. In the cohort, 45 (56%) patients had tetralogy of Fallot. While 53 (65%) patients received a Melody valve, a Sapien valve (S3 in 20, XT in eight) was implanted in the rest. Pre-stenting was performed in 49 (52%) patients. One patient died of severe heart failure a year following TPVR. One patient had a second TPVR performed 2.2 years following initial TPVR for severe pulmonary regurgitation. Valve survival at 2.2 years was 94% (95% CI: 87-100%). Four patients developed endocarditis. Endocarditis-free survival was 89% (95% CI: 80-100%) at three years.
CONCLUSIONS: Our experience suggests favorable results of TPVR in adults with congenital heart disease. Additional research would be warranted with a focus on total valve longevity and patient reported outcomes, in order to improve the understanding of TPVR in this population and further refine this technology.
Keywords
Pulmonary valve, adult congenital heart disease, transcatheter valve replacement
Published Open-Access
yes
Recommended Citation
Spigel, Zachary A; Adachi, Iki; Binsalamah, Ziyad M; et al., "Transcatheter Pulmonic Valve Implantation in Adult Patients With Prior Congenital Heart Surgery" (2021). Faculty and Staff Publications. 976.
https://digitalcommons.library.tmc.edu/baylor_docs/976