Publication Date
8-29-2023
Journal
Proceedings of the National Academy of Sciences of the United States of America
DOI
10.1073/pnas.2304112120
PMID
37607236
PMCID
PMC10469030
PubMedCentral® Posted Date
8-22-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
no
Keywords
White Matter, Phosphorylation, Myelin Sheath, Wnt Signaling Pathway, Daam2, CK2α, Wnt, oligodendrocyte, white matter injury
Abstract
Wnt signaling plays a vital role in oligodendrocyte (OL) development and has been implicated as an adverse event for myelin repair after white matter injury. Emerging studies have shed light on multimodal roles of Wnt effectors in the OL lineage, but the underlying molecular mechanisms and modifiable targets in OL remyelination remain unclear. Using genetic mouse development and injury model systems, we delineate a unique stage-specific function of Daam2 in Wnt signaling and OL development via a S704/T705 phosphorylation mechanism and determine a different role of the kinase CK2α in the regulation of OL development and myelin regeneration.
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