Modulation of Energetic and Lipid Pathways by Curcumin as a Potential Chemopreventive Strategy in Human Prostate Cancer Cells

Authors

Michele Pellegrino
Maria Antonietta Occhiuzzi
Fedora Grande
Ilaria Stefania Pagani
Stefano Aquaro
Paola Tucci

Language

English

Publication Date

11-26-2024

Journal

Biochemical and Biophysical Research Communications

DOI

10.1016/j.bbrc.2024.150477

PMID

3909688

Abstract

In Western industrialized countries, prostate cancer (PCa) is the second most common malignant disease and prevalent cause of death for men. Epidemiological studies have shown that curcumin (CUR) either prevents PCa initiation or delays its progression to a more aggressive and treatment-refractory form, thus reducing related mortality. Our previous studies have proven the anticancer, antioxidant, and anti-inflammatory properties of CUR on PCa cells. However, there are few reports of the effect of CUR on energy and lipid pathways in PCa. Herein, we show that CUR can modulate the two metabolic energy pathways, increasing glycolytic reserve and reducing oxidative phosphorylation. Moreover, through the regulation of key enzymes and proteins, CUR affected the lipid pathway in PC-3 to a greater extent compared to the healthy PNT-2 cells. According to molecular docking investigations, the CUR activity in PCa may be mediated by the direct binding to the pyruvate dehydrogenase (PDHA1) enzyme, which is essential for regulating the appropriate mitochondrial activity. Taken together, our results shed light on the mechanism of action of CUR in the PCa cell metabolism and provide evidence of its potential value as an anticancer metabolic modulator, paving opportunities for novel therapeutic strategies.

Keywords

Curcumin, Humans, Male, Prostatic Neoplasms, Cell Line, Tumor, Lipid Metabolism, Energy Metabolism, Molecular Docking Simulation, Oxidative Phosphorylation, Glycolysis, Antineoplastic Agents, Pyruvate Dehydrogenase (Lipoamide), Chemoprevention, Metabolic reprogramming, Molecular docking, Natural compound, Prostate carcinoma.

Published Open-Access

yes

Recommended Citation

Pellegrino, Michele; Occhiuzzi, Maria Antonietta; Grande, Fedora; et al., "Modulation of Energetic and Lipid Pathways by Curcumin as a Potential Chemopreventive Strategy in Human Prostate Cancer Cells" (2024). Staff and Researcher Publications. 39.
https://digitalcommons.library.tmc.edu/clinic_pub/39