Staff and Researcher Publications
Language
English
Publication Date
8-1-2022
Journal
Biological Psychiatry
DOI
10.1016/j.biopsych.2021.11.007
PMID
35063186
PMCID
PMC9124238
PubMedCentral® Posted Date
8-1-2023
PubMedCentral® Full Text Version
Author MSS
Abstract
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.
Keywords
Deep Brain Stimulation, Depression, Depressive Disorder, Treatment-Resistant, Double-Blind Method, Humans, Parkinson Disease, Quality of Life, deep brain stimulation, neuromodulation, stereo-EEG, network, epilepsy, depression
Published Open-Access
yes
Recommended Citation
Sheth, Sameer A; Bijanki, Kelly R; Metzger, Brian; et al., "Deep Brain Stimulation for Depression Informed by Intracranial Recordings" (2022). Staff and Researcher Publications. 52.
https://digitalcommons.library.tmc.edu/clinic_pub/52
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Medical Sciences Commons, Mental and Social Health Commons, Psychiatry and Psychology Commons