Staff and Researcher Publications

Language

English

Publication Date

9-9-2022

Journal

Journal of the National Cancer Institute

DOI

10.1093/jnci/djac061

PMID

35438160

PMCID

PMC9468294

PubMedCentral® Posted Date

4-19-2022

PubMedCentral® Full Text Version

Post-print

Abstract

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

Keywords

Adult, Body Mass Index, Body Size, Cohort Studies, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Neoplasms, Obesity, Prospective Studies

Published Open-Access

yes

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