The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress.

Authors

Michelle A Patriquin
Sanjay J Mathew

Language

English

Publication Date

1-1-2017

Journal

Chronic Stress

DOI

10.1177/2470547017703993

PMID

29503978

PMCID

PMC5832062

PubMedCentral® Posted Date

6-8-2017

PubMedCentral® Full Text Version

Post-print

Abstract

Two classification systems are now at the forefront of clinical psychiatric research: (1) Diagnostic and Statistical Manual, Fifth Edition and (2) the National Institutes of Mental Health Research Domain Criteria. Herein, we propose that these two classification systems are complementary rather than mutually exclusive, and when combined provide important information for understanding aspects of the pathophysiology related to Generalized Anxiety Disorder (GAD). The neurobiological literature for GAD and one relevant research domain criteria component, sustained threat, are reviewed from multiple units of analysis (genetic, neuroimaging, neuroendocrine, and psychophysiological). It is hypothesized that generating a comprehensive, biologically based understanding of the relationship between GAD, sustained threat, and the measureable units of analysis will provide information critical to design the most effective treatments.

Keywords

brain imaging/neuroimaging, genetics, biological markers, anxiety, stress

Published Open-Access

yes

Recommended Citation

Michelle A Patriquin and Sanjay J Mathew, "The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress." (2017). Staff and Researcher Publications. 80.
https://digitalcommons.library.tmc.edu/clinic_pub/80