Staff and Researcher Publications
Language
English
Publication Date
1-1-2022
Journal
Chronic Stress
DOI
10.1177/24705470221083700
PMID
35340866
PMCID
PMC8941704
PubMedCentral® Posted Date
3-21-2022
PubMedCentral® Full Text Version
Author MSS
Abstract
Background: Brain imaging and genetics are fields acquiring data at increasing speed, but more information does not always result in a better understanding of the underlying biology. We developed the ProcessGeneLists (PGL) approach to use genetics and mRNA gene expression data to generate regions of interest for imaging studies.
Methods: We applied PGL to past suicide attempt (ATT): We averaged the mRNA expression levels of genes (n = 130) possibly associated with ATT (p ≤ 10-3 in a published genome-wide association study, GWAS) in each brain region studied in the Human Allen Brain Atlas (6 ex-vivo brains, 158 to 946 regions/brain have mRNA expression data) and compared that to the averaged mRNA expression levels of all other genes in each region in each brain in the atlas.
Results: PGL revealed 8 regions where "attempt-related genes" were differentially expressed (Wilcoxon test with Bonferroni correction 8.88-11 =
Conclusion: PGL uncovered a brain function/genotype interaction in ATT by using published GWAS data to inform imaging studies. This could inform individualized therapies in the future.
Keywords
AKAP-7, dorsolateral prefrontal cortex, habenula, subiculum, suicide, resting state functional connectivity
Published Open-Access
yes
Recommended Citation
Poblete, Guillermo; Nguyen, Tien; Gosnell, Savannah; et al., "A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality" (2022). Staff and Researcher Publications. 82.
https://digitalcommons.library.tmc.edu/clinic_pub/82
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