Staff and Researcher Publications

Language

English

Publication Date

1-1-2025

Journal

Alzheimer's & Dementia

DOI

10.1002/alz.14399

PMID

39641363

PMCID

PMC11772730

PubMedCentral® Posted Date

12-6-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Introduction: The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is evaluating lifestyle interventions in older adults at risk for cognitive decline and dementia. Here we characterize the baseline data set of the POINTER Imaging ancillary study.

Methods: Participants underwent health and cognitive assessments and neuroimaging with multimodal positron emission tomography (PET) (beta-amyloid [Aβ] and tau) and magnetic resonance imaging (MRI). Framingham risk score (FRS) was used to quantify cardiovascular disease (CVD) risk.

Results: A total of 1052 participants (31% from underrepresented ethnoracial groups) were enrolled. Compared to Aβ-, Aβ+ (29%) participants were older, had higher apolipoprotein E (APOE) ε4 carriage rate and white matter hyperintensity volume, and greater temporal tau. FRS was related to MRI measures, but not AD biomarkers. FRS and tau had independent effects on cognition.

Discussion: In this heterogenous, at-risk cohort, CVD risk was related to more abnormal brain structure and poorer cognition, representing a putative non-AD (Alzheimer's disease) pathway to brain injury and cognitive decline.

Highlights: ·The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort is enriched for cardiovascular disease (CVD) and poor lifestyle ·POINTER Imaging collected multimodal neuroimaging data in this unique, at-risk cohort ·Amyloid burden was related to age, apolipoprotein E (APOE) ε4 carriage, and measures of disease progression ·Associations between amyloid and tau, and tau and cognition, were relatively weak ·CVD risk and tau pathology were independently related to memory.

Keywords

Humans, Male, Female, Aged, Magnetic Resonance Imaging, Positron-Emission Tomography, Biomarkers, tau Proteins, Cardiovascular Diseases, Brain, Amyloid beta-Peptides, Cohort Studies, Neuroimaging, Cognition, Middle Aged, Multimodal Imaging, Cognitive Dysfunction, Apolipoprotein E4, Aged, 80 and over, Neuropsychological Tests, amyloid, cerebrovascular injury, Framingham risk score, memory, minoritized groups, MRI, PET, preclinical Alzheimer's disease, tau

Published Open-Access

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