The association of caffeine intake with components of lower urinary tract symptoms (LUTS) among cancer survivors
Abstract
Lower Urinary Tract Symptoms (LUTS) is one of the most common and highly prevalent urological complaints in the population who are above the age of 40. Many medical advices recommend LUTS patients to limit certain beverages, especially caffeinated beverages. However, the association between caffeine intake and the progression of LUTS has not been confirmed yet, especially in cancer survivors. It is highly suggested that LUTS is aggravated by urological, female hormonal, and gynecological cancers and the treatments of these cancers possibly because of their locations in the urological area which effect muscles controlling urination and surrounding nerves. Despite of these suggestions, no confirmed associations were established in the literature. In this analysis, we used the population based National Health and Examination Survey (NHANES) data from 1999 to 2012 to investigate the association between self-reported caffeine intake and two components of LUTS (stress urinary incontinence and nocturia) among cancer survivors. We found that the prevalence of stress urinary incontinence among caffeine consumers in male cancer survivors was 30.65% compared to 1.48% in non-caffeine consumers, while the prevalence was as high as 47.67% in female caffeine consumers compared to 6.48% in non-caffeine consumers. Approximately half of the male caffeine consumers suffered from nocturia as the prevalence was 46.34% compared to 2.26% in non-caffeine consumers. 36.78% of female cancer survivors who consumed caffeine reported nocturia compared to 5.14% in non-caffeine consumers. We used weighted, multivariate logistic regression models to examine the association of caffeine intake with components of LUTS. We found that caffeine consumption was not associated with stress urinary incontinence in men. In women, an association was observed between stress urinary incontinence and caffeine intake of 326-450 mg/day in the multivariate analysis, however this association did not reach statistical significance (OR: 1.85, 95% CI [0.27-12.7]). Nocturia was not associated with caffeine intake in men. In women, a statistically significant negative association was observed between caffeine intake of 201-325 mg/day and the intake of >451 mg/day of caffeine and nocturia (OR:0.03, 95% CI [0.001-0.47], and OR: 0.02, 95% CI [0.001-0.86], respectively). Confirmation of these findings in other studies is needed in order to determine that caffeine intake is not associated with components of LUTS.
Subject Area
Public health|Epidemiology
Recommended Citation
Anan, Hadeel F, "The association of caffeine intake with components of lower urinary tract symptoms (LUTS) among cancer survivors" (2016). Texas Medical Center Dissertations (via ProQuest). AAI10183278.
https://digitalcommons.library.tmc.edu/dissertations/AAI10183278