Investigating Associations Between Mechanism of Anticoagulant-Associated Major Bleeding and Length of Hospital Stay

Olivia Mahlmann, The University of Texas School of Public Health

Abstract

Oral anticoagulants are the most common cause of adverse drug events in inpatient settings in the United States. A known side effect of oral anticoagulation therapy is increased bleeding risk. There is little research available on the mechanism of oral anticoagulant-associated major bleeding (e.g. traumatic vs. non-traumatic), and its effect on length of hospital stay. A bleed is considered to be traumatic if an injury mechanism is involved. If no injury mechanism is involved, the bleed is considered to be non-traumatic. This retrospective, secondary data analysis investigates associations between traumatic and non-traumatic major bleeds and length of hospital stay. A subset of 93 participants, who presented to a network of five Seton hospitals in Austin, Texas with a major bleeding event while on oral anticoagulant therapy, was analyzed. Bivariate and multivariate linear regression models were fit to examine significant differences in the length of hospital stay by major bleed mechanism, adjusted for potential confounding effects. No significant differences in length of hospital stay and major bleed mechanism were found, both before and after adjusting for potential confounders (p>0.05). Recommendations for future research include prospective studies investigating the effect of oral anticoagulants on major bleed mechanism, and the association between oral anticoagulant-related major bleed mechanism and length of hospital stay.

Subject Area

Medicine|Public health|Epidemiology

Recommended Citation

Mahlmann, Olivia, "Investigating Associations Between Mechanism of Anticoagulant-Associated Major Bleeding and Length of Hospital Stay" (2018). Texas Medical Center Dissertations (via ProQuest). AAI10790640.
https://digitalcommons.library.tmc.edu/dissertations/AAI10790640

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