Duncan NRI Faculty and Staff Publications
Language
English
Publication Date
3-4-2022
Journal
Science
DOI
10.1126/science.abk2432
PMID
35239393
PMCID
PMC8944923
PubMedCentral® Posted Date
3-24-2022
PubMedCentral® Full Text Version
Author MSS
Abstract
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
Keywords
Animals, Cell Nucleus, Databases, Genetic, Drosophila Proteins, Drosophila melanogaster, Female, Gene Expression Regulation, Gene Regulatory Networks, Genes, Insect, Male, RNA-Seq, Sex Characteristics, Single-Cell Analysis, Transcription Factors, Transcriptome
Published Open-Access
yes
Recommended Citation
Li, Hongjie; Janssens, Jasper; De Waegeneer, Maxime; et al., "Fly Cell Atlas: A Single-Nucleus Transcriptomic Atlas of the Adult Fruit Fly" (2022). Duncan NRI Faculty and Staff Publications. 120.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/120
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Genetic Phenomena Commons, Medical Genetics Commons, Neurology Commons, Neurosciences Commons