Duncan NRI Faculty and Staff Publications
Language
English
Publication Date
9-4-2025
Journal
American Journal of Human Genetics
DOI
10.1016/j.ajhg.2025.07.012
PMID
40829599
PMCID
PMC12461002
PubMedCentral® Posted Date
8-18-2025
PubMedCentral® Full Text Version
Post-print
Abstract
We present the Causal Pivot (CP) as a structural causal model (SCM) for analyzing genetic heterogeneity in complex diseases. The CP leverages an established causal factor or factors to detect the contribution of additional suspected causes. Specifically, polygenic risk scores (PRSs) serve as known causes, while rare variants (RVs) or RV ensembles are evaluated as candidate causes. The CP incorporates outcome-induced association by conditioning on disease status. We derive a conditional maximum-likelihood procedure for binary and quantitative traits and develop the Causal Pivot likelihood ratio test (CP-LRT) to detect causal signals. Through simulations, we demonstrate the CP-LRT's robust power and superior error control compared to alternatives. We apply the CP-LRT to UK Biobank (UKB) data, analyzing three exemplar diseases: hypercholesterolemia (HC, low-density lipoprotein cholesterol ≥4.9 mmol/L; n
Keywords
Humans, Genetic Heterogeneity, Breast Neoplasms, Multifactorial Inheritance, Parkinson Disease, Genetic Predisposition to Disease, Female, Models, Genetic, Genetic Variation, Likelihood Functions, Genome-Wide Association Study, causal inference, genetic heterogeneity, complex disease, collider, rare variation, polygenic risk score
Published Open-Access
yes
Recommended Citation
Shaw, Chad A; Williams, C J; Tan, Taotao; et al., "The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases" (2025). Duncan NRI Faculty and Staff Publications. 123.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/123
Included in
Genetic Phenomena Commons, Medical Genetics Commons, Neurology Commons, Neurosciences Commons