Duncan NRI Faculty and Staff Publications

Language

English

Publication Date

6-16-2023

Journal

Science

DOI

10.1126/science.adg0934

PMID

37319212

PMCID

PMC10829769

PubMedCentral® Posted Date

1-31-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We characterize 163 distinct cell types and perform an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further develop aging clock models to predict the fly age and show that ribosomal gene expression is a conserved predictive factor for age. Combining all aging features, we find unique cell type-specific aging patterns. This atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.

Keywords

Animals, Aging, Cellular Senescence, Gene Expression Profiling, Transcriptome, Drosophila melanogaster, Atlases as Topic, aging, Drosophila, single-nucleus RNA-seq, cell atlas

Published Open-Access

yes

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