Sox9 Directs Divergent Epigenomic States in Brain Tumor Subtypes

Authors

Debosmita Sardar
Hsiao-Chi Chen
Amanda Reyes
Srinidhi Varadharajan
Antrix Jain
Carrie Mohila
Rachel Curry
Brittney Lozzi
Kavitha Rajendran
Alexis Cervantes
Kwanha Yu
Ali Jalali
Ganesh Rao
Stephen C Mack
Benjamin Deneen

Language

English

Publication Date

7-19-2022

Journal

Proceedings of the National Academy of Sciences of the United States of America

DOI

10.1073/pnas.2202015119

PMID

35858326

PMCID

PMC9303974

PubMedCentral® Posted Date

7-15-2022

PubMedCentral® Full Text Version

Post-print

Abstract

Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible for these diverse epigenetic states remain unclear. Here, we show that the developmental transcription factor Sox9 differentially regulates epigenomic states in high-grade glioma (HGG) and ependymoma (EPN). Using our autochthonous mouse models, we found that Sox9 suppresses HGG growth and expands associated H3K27ac states, while promoting ZFTA-RELA (ZR

Keywords

Animals, Brain Neoplasms, Carcinogenesis, Ependymoma, Epigenesis, Genetic, Mice, Neoplasms, Experimental, SOX9 Transcription Factor, high-grade glioma, ependymoma, epigenetics, histone, transcription

Published Open-Access

yes

Recommended Citation

Sardar, Debosmita; Chen, Hsiao-Chi; Reyes, Amanda; et al., "Sox9 Directs Divergent Epigenomic States in Brain Tumor Subtypes" (2022). Duncan NRI Faculty and Staff Publications. 148.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/148