KMT2D Temporally Activates Neuronal Transcriptional Factor Genes To Mediate Cerebellar Granule Cell Differentiation

Authors

Shilpa S Dhar
Kyung-Pil Ko
Jinho Jang
Calena Brown-Abel
Tao Lin
Sharad Awasthi
Kaifu Chen
Roy V Sillitoe
Jae-Il Park
Min Gyu Lee

Language

English

Publication Date

9-26-2025

Journal

Science Advances

DOI

10.1126/sciadv.adu7174

PMID

41004595

PMCID

PMC12467062

PubMedCentral® Posted Date

9-26-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Spatiotemporal gene expression is the fundamental feature of cellular differentiation, including neuron differentiation. The epigenetic mechanism underlying spatiotemporal gene regulation during in vivo neuron differentiation remains largely unknown. Granule cells (GCs) constitute the vast majority of neurons in the cerebellum, which contains most of neurons in the brain. Here, we show that

Keywords

Animals, Female, Male, Mice, Cerebellum, Gene Expression Regulation, Developmental, Mice, Knockout, Neurogenesis, Histone-Lysine N-Methyltransferase, Myeloid-Lymphoid Leukemia Protein, Basic Helix-Loop-Helix Transcription Factors

Published Open-Access

yes

Recommended Citation

Dhar, Shilpa S; Ko, Kyung-Pil; Jang, Jinho; et al., "KMT2D Temporally Activates Neuronal Transcriptional Factor Genes To Mediate Cerebellar Granule Cell Differentiation" (2025). Duncan NRI Faculty and Staff Publications. 174.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/174