The Cerebellum Modulates Thirst

Authors

Ila Mishra
Bing Feng
Bijoya Basu
Amanda M Brown
Linda H Kim
Tao Lin
Mir Abbas Raza
Amelia Moore
Abigayle Hahn
Samantha Bailey
Alaina Sharp
Juan C Bournat
Claire Poulton
Brian Kim
Amos Langsner
Aaron Sathyanesan
Roy V Sillitoe
Yanlin He
Atul R Chopra

Language

English

Publication Date

9-1-2024

Journal

Nature Neuroscience

DOI

10.1038/s41593-024-01700-9

PMID

38987435

PMCID

PMC12210242

PubMedCentral® Posted Date

7-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Recent studies have implicated the cerebellum in cognition, sensation, emotion and autonomic function, making it an important target for further investigation. Here, we show that cerebellar Purkinje neurons in mice are activated by the hormone asprosin, leading to enhanced thirst, and that optogenetic or chemogenetic activation of Purkinje neurons induces rapid manifestation of water drinking. Purkinje neuron-specific asprosin receptor (Ptprd) deletion results in reduced water intake without affecting food intake and abolishes asprosin's dipsogenic effect. Purkinje neuron-mediated motor learning and coordination were unaffected by these manipulations, indicating independent control of two divergent functions by Purkinje neurons. Our results show that the cerebellum is a thirst-modulating brain area and that asprosin-Ptprd signaling may be a potential therapeutic target for the management of thirst disorders.

Keywords

Animals, Thirst, Mice, Cerebellum, Purkinje Cells, Male, Mice, Inbred C57BL, Drinking, Optogenetics, Mice, Transgenic, Mice, Knockout, Nerve Tissue Proteins

Published Open-Access

yes

Recommended Citation

Mishra, Ila; Feng, Bing; Basu, Bijoya; et al., "The Cerebellum Modulates Thirst" (2024). Duncan NRI Faculty and Staff Publications. 175.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/175