Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control.

Authors

Aryn H Gittis
Roy V Sillitoe

Language

English

Publication Date

8-1-2024

Journal

Annual Review of Neuroscience

DOI

10.1146/annurev-neuro-092823-104810

PMID

38424473

Abstract

Deep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie motor control. In parallel, insights from basic science about how patterns of electrical stimulation impact plasticity and communication within neural circuits are transforming DBS from a therapy for treating symptoms to a therapy for treating circuits, with the goal of training the brain out of its diseased state.

Keywords

Deep Brain Stimulation, Humans, Parkinson Disease, Animals, Brain, Movement, Dystonia, Nerve Net, Neural Pathways, Neuronal Plasticity, Parkinson's disease; basal ganglia; cerebellum; deep brain stimulation; dystonia

Published Open-Access

yes

Recommended Citation

Aryn H Gittis and Roy V Sillitoe, "Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control." (2024). Duncan NRI Faculty and Staff Publications. 177.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/177