Cerebellar Functions Beyond Movement and Learning

Authors

Linda H Kim
Detlef H Heck
Roy V Sillitoe

Language

English

Publication Date

8-1-2024

Journal

Annual Review of Neuroscience

DOI

10.1146/annurev-neuro-100423-104943

PMID

38663092

Abstract

The cerebellum has a well-established role in controlling motor functions, including coordination, posture, and the learning of skilled movements. The mechanisms for how it carries out motor behavior remain under intense investigation. Interestingly though, in recent years the mechanisms of cerebellar function have faced additional scrutiny since nonmotor behaviors may also be controlled by the cerebellum. With such complexity arising, there is now a pressing need to better understand how cerebellar structure, function, and behavior intersect to influence behaviors that are dynamically called upon as an animal experiences its environment. Here, we discuss recent experimental work that frames possible neural mechanisms for how the cerebellum shapes disparate behaviors and why its dysfunction is catastrophic in hereditary and acquired conditions-both motor and nonmotor. For these reasons, the cerebellum might be the ideal therapeutic target.

Keywords

Cerebellum, Animals, Humans, Learning, Movement, cerebellum, cognition, learning, movement, reward, sleep

Published Open-Access

no

Recommended Citation

Linda H Kim, Detlef H Heck, and Roy V Sillitoe, "Cerebellar Functions Beyond Movement and Learning" (2024). Duncan NRI Faculty and Staff Publications. 178.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/178