Synaptic Alterations in Pyramidal Cells Following Genetic Manipulation of Neuronal Excitability in Monkey Prefrontal Cortex

Authors

Guillermo Gonzalez-Burgos
Takeaki Miyamae
Yosuke Nishihata
Olga L Krimer
Kirsten Wade
Kenneth N Fish
Dominique Arion
Zhao-Lin Cai
Mingshan Xue
William R Stauffer
David A Lewis

Language

English

Publication Date

2-1-2025

Journal

Journal of Neurophysiology

DOI

10.1152/jn.00326.2024

PMID

39740351

PMCID

PMC12208097

PubMedCentral® Posted Date

6-30-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The primate dorsolateral prefrontal cortex (DLPFC) displays unique in vivo activity patterns, but how in vivo activity regulates DLPFC pyramidal neuron (PN) properties remains unclear. We assessed the effects of in vivo Kir2.1 overexpression, a genetic silencing tool, on synapses in monkey DLPFC PNs. We show for the first time that recombinant ion channel expression successfully modifies the excitability of primate cortex neurons, producing effects on synaptic properties apparently different from those in the rodent cortex.

Keywords

Animals, Pyramidal Cells, Synapses, Potassium Channels, Inwardly Rectifying, Prefrontal Cortex, Macaca mulatta, Male, Excitatory Postsynaptic Potentials

Published Open-Access

yes

Recommended Citation

Gonzalez-Burgos, Guillermo; Miyamae, Takeaki; Nishihata, Yosuke; et al., "Synaptic Alterations in Pyramidal Cells Following Genetic Manipulation of Neuronal Excitability in Monkey Prefrontal Cortex" (2025). Duncan NRI Faculty and Staff Publications. 188.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/188