Focused Ultrasound Thalamotomy: Correlation of Postoperative Imaging with Neuropathological Findings

Authors

• Sarah E Blitz
• Matthew Torre
• Melissa M J Chua
• Sarah L Christie
• Nathan J McDannold
• G Rees Cosgrove

Language

English

Publication Date

1-1-2023

Journal

Stereotactic and Functional Neurosurgery

DOI

10.1159/000527269

PMID

36696893

PMCID

PMC9981195

PubMedCentral® Posted Date

1-25-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) is a rapidly developing technique used for tremor relief in tremor-predominant Parkinson's disease (PD) and essential tremor that has demonstrated successful results. Here, we describe the neuropathological findings in a woman who died from a fall 10 days after successful MRgFUS for tremor-predominant PD. Histological analysis demonstrates the characteristic early postoperative MRI findings including 3 distinct zones on T2-weighted imaging: (1) a hypointense core, (2) a hyperintense region with hypointense rim, and (3) a slightly hyperintense, poorly marginated surrounding area. Histopathological analyses also demonstrate the suspected cellular processes composing each of these regions including central hemorrhagic necrosis with surrounding cytotoxic edema and a rim of mostly unaffected vasogenic edema with some reactive and reparative processes. Overall, this case demonstrates the correlation of postoperative imaging findings with the subacute neuropathological findings after MRgFUS for PD.

Keywords

Female, Humans, Tremor, Treatment Outcome, Thalamus, Nervous System Diseases, Magnetic Resonance Imaging, Essential Tremor, Parkinson Disease

Published Open-Access

yes

Recommended Citation

Blitz, Sarah E; Torre, Matthew; Chua, Melissa M J; et al., "Focused Ultrasound Thalamotomy: Correlation of Postoperative Imaging with Neuropathological Findings" (2023). Duncan NRI Faculty and Staff Publications. 248.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/248