Glial Lipid Droplets Resolve ROS During Sleep

Authors

Lindsey D Goodman
Matthew J Moulton
Hugo J Bellen

Publication Date

4-1-2024

Journal

Nature Neuroscience

DOI

10.1038/s41593-023-01546-7

PMID

38360945

PMCID

PMC11929967

PubMedCentral® Posted Date

3-23-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Reactive Oxygen Species, Lipid Droplets, Neuroglia, Neurons, Sleep, Lipid Metabolism

Abstract

The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species (ROS). This promotes neuronal function after an active day. Hence, this pathway has an important physiological function beyond its previously described role in ROS-associated diseases, including Alzheimer’s disease.