Duncan NRI Faculty and Staff Publications
Language
English
Publication Date
10-27-2022
Journal
Nature Communications
DOI
10.1038/s41467-022-33883-9
PMID
36302912
PMCID
PMC9613627
PubMedCentral® Posted Date
10-27-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase–followed by a prolonged decrease–in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.
Keywords
Mice, Animals, Feedback, Interneurons, Pyramidal Cells, Vasoactive Intestinal Peptide, Extrastriate cortex, Barrel cortex
Published Open-Access
yes
Recommended Citation
Shen, Shan; Jiang, Xiaolong; Scala, Federico; et al., "Distinct Organization of Two Cortico-Cortical Feedback Pathways" (2022). Duncan NRI Faculty and Staff Publications. 74.
https://digitalcommons.library.tmc.edu/duncar_nri_pub/74
Included in
Genetic Phenomena Commons, Medical Genetics Commons, Neurology Commons, Neurosciences Commons