Children’s Nutrition Research Center Staff Publications
Language
English
Publication Date
10-27-2022
Journal
PLoS One
DOI
10.1371/journal.pone.0275242
PMID
36301862
PMCID
PMC9612448
PubMedCentral® Posted Date
10-27-2022
PubMedCentral® Full Text Version
Post-print
Abstract
In a published randomized controlled trial, household units were randomized to a nutrient bar supplementation group or a control condition, but the non-independence of observations within the same household (i.e., the clustering effect) was not accounted for in the statistical analyses. Therefore, we reanalyzed the data appropriately by adjusting degrees of freedom using the between-within method, and accounting for household units using linear mixed effect models with random intercepts for family units and subjects nested within family units for each reported outcome. Results from this reanalysis showed that ignoring the clustering and nesting effects in the original analyses had resulted in anticonservative (i.e., too small) time x group interaction p-values. Still, majority of the conclusions remained unchanged.
Keywords
Adult, Humans, Adolescent, Cluster Analysis, Dietary Supplements, Metabolome, Family, Cardiovascular Diseases, Nutrients
Published Open-Access
yes
Recommended Citation
Jamshidi-Naeini, Yasaman; Golzarri-Arroyo, Lilian; Vorland, Colby J; et al., "Accounting for the Clustering and Nesting Effects Verifies Most Conclusions. Corrected Analysis Of: “Randomized Nutrient Bar Supplementation Improves Exercise-Associated Changes in Plasma Metabolome in Adolescents and Adult Family Members at Cardiometabolic Risk”" (2022). Children’s Nutrition Research Center Staff Publications. 210.
https://digitalcommons.library.tmc.edu/staff_pub/210
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Dietetics and Clinical Nutrition Commons, Endocrinology, Diabetes, and Metabolism Commons, Nutrition Commons