Birth Weight Moderates the Association Between Obesity and Mortality Rate

Authors

Gregory Pavela
Nengjun Yi
Luis Mestre
Pengcheng Xun
David B Allison

Language

English

Publication Date

6-1-2023

Journal

Annals of Epidemiology

DOI

10.1016/j.annepidem.2023.03.010

PMID

37015307

PMCID

PMC10463462

PubMedCentral® Posted Date

8-29-2023

PubMedCentral® Full Text Version

Author MSS

Abstract

Purpose: The strength of the association between obesity and mortality rate (MR) varies by body mass index (BMI) and sociodemographic groups. We test the hypothesis that the association between obesity and MR varies, in part, due to the moderating effect of parental BMI and birth weight.

Methods: Data come from the 1958 National Child Development Study, an ongoing longitudinal dataset initiated in 1958 with baseline measures of birth weight from 18,059 infants born in Great Britain over 1 week. We tested whether the association between BMI and MR was moderated by parental BMI and birth weight using generalized additive proportional hazards models.

Results: The association between adult BMI and MR was moderated by birth weight and maternal BMI, such that the association between BMI and MR was weaker among individuals with a higher birth weight (P = .0148) and stronger among individuals born to mothers with a higher BMI (P = .032). At any given level of BMI approximately greater than 25, individuals with low birth weight or born to mothers with a higher BMI, had a higher MR. Paternal BMI did not significantly modify the relationship between BMI and MR (P = .5168).

Conclusions: Results suggest that the relationship between obesity and MR is modified by birth weight and maternal BMI.

Keywords

Infant, Male, Female, Child, Adult, Humans, Birth Weight, Obesity, Mothers, Body Mass Index, Longitudinal Studies, Birth Weight, Obesity, Mortality, Life Course, Development Origins of Health and Disease

Published Open-Access

yes

Recommended Citation

Pavela, Gregory; Yi, Nengjun; Mestre, Luis; et al., "Birth Weight Moderates the Association Between Obesity and Mortality Rate" (2023). Children’s Nutrition Research Center Staff Publications. 220.
https://digitalcommons.library.tmc.edu/staff_pub/220