Children’s Nutrition Research Center Staff Publications
Language
English
Publication Date
1-1-2024
Journal
Frontiers in Immunology
DOI
10.3389/fimmu.2024.1385022
PMID
38694507
PMCID
PMC11061843
PubMedCentral® Posted Date
4-17-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Liver failure represents a critical medical condition with a traditionally grim prognosis, where treatment options have been notably limited. Historically, liver transplantation has stood as the sole definitive cure, yet the stark disparity between the limited availability of liver donations and the high demand for such organs has significantly hampered its feasibility. This discrepancy has necessitated the exploration of hepatocyte transplantation as a temporary, supportive intervention. In light of this, our review delves into the burgeoning field of hepatocyte transplantation, with a focus on the latest advancements in maintaining hepatocyte function, co-microencapsulation techniques, xenogeneic hepatocyte transplantation, and the selection of materials for microencapsulation. Our examination of hepatocyte microencapsulation research highlights that, to date, most studies have been conducted
Keywords
Animals, Humans, Cell Encapsulation, Cell Survival, Hepatocytes, Liver Failure, Transplantation, Heterologous, hepatocyte encapsulation, microencapsulation, coculture, xenotransplantation, alginate
Published Open-Access
yes
Recommended Citation
Wang, Hailian; Wen, Lebin; Jiang, Fengdi; et al., "A Comprehensive Review of Advances in Hepatocyte Microencapsulation: Selecting Materials and Preserving Cell Viability" (2024). Children’s Nutrition Research Center Staff Publications. 317.
https://digitalcommons.library.tmc.edu/staff_pub/317
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Dietetics and Clinical Nutrition Commons, Endocrinology, Diabetes, and Metabolism Commons, Nutrition Commons