ST-Segment Elevation Myocardial Infarction and Bleeding Complications in JAK2-Negative Polycythemia

Authors

Priscilla Duran Luciano
Vanessa Sabella-Jiménez

Publication Date

9-1-2023

Journal

The Texas Heart Journal

DOI

10.14503/THIJ-23-8148

PMID

37872693

Publication Date(s)

September 2023

Language

English

PMCID

PMC10658142

PubMedCentral® Posted Date

10-23-2023

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

Humans, Polycythemia, Polycythemia Vera, ST Elevation Myocardial Infarction, Myocardial Infarction, Thrombosis, Janus Kinase 2

Copyright

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Abstract

Thrombotic and bleeding complications are major causes of morbidity and mortality in patients with polycythemia vera, who predominantly present with an alteration in the JAK2 gene. Because of their hypercoagulable state and risk of hemorrhage, patients with polycythemia vera who present with an acute myocardial infarction pose a challenge to physicians. This case report describes the presentation and treatment of a Hispanic patient with JAK2 V617F-negative primary polycythemia who developed cardiac arrest and ST-segment elevation myocardial infarction owing to complete occlusion of the left anterior descending artery as well as bleeding complications and postmyocardial pericarditis.