Language
English
Publication Date
1-1-2024
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-23-8210
PMID
38686683
PMCID
PMC11075508
PubMedCentral® Posted Date
5-1-2024
PubMedCentral® Full Text Version
Post-Print
Abstract
BACKGROUND: Previous studies have established a positive correlation between serum uric acid to creatinine (SUA/Cr) ratio and cardiovascular disease, but the relationship between SUA/Cr ratio and the prognosis of heart failure (HF) remains unknown. This study investigated the potential of SUA/Cr ratio as a prognostic predictor for patients with HF.
METHODS: This single-center prospective cohort study enrolled 2,122 patients with HF between March 2013 and June 2017. All patients were divided into 3 groups according to SUA/Cr ratio tertiles and were followed up with until December 31, 2022. The association between SUA/Cr ratio and the prognosis of HF was assessed using the Cox proportional hazards model.
RESULTS: The mean (SD) age and mean (SD) SUA/Cr ratio of the study cohort (66% male) were 59.3 (14.7) years and 4.71 (2.09), respectively. During a median follow-up period of 15 months (range, 11-26 months), 390 end-point events were observed. Prognosis analysis revealed that a high SUA/Cr ratio was associated with an increased mortality risk of HF (hazard ratio, 1.62 [95% CI, 1.26-2.09]; P < .001) compared with the SUA/Cr ratio in the lowest tertile. After adjusting for covariates, the hazard ratio for mortality risk of HF was 1.71 (95% CI, 1.23-2.37; P = .001). Subgroup analysis showed that mortality risk increased in direct proportion with the SUA/Cr ratio in female patients, patients with a history of hypertension and β-blocker use, and patients with UA levels below 428 μmol/L and creatinine levels less than 97 mg/dL. Stratification by age; by history of diabetes, hyperlipidemia, and smoking; and by level of fasting plasma glucose, however, had no obvious effect on the association between SUA/Cr ratio and HF prognosis. Patients with higher SUA/Cr ratios had reduced left ventricular ejection fraction and increased left ventricular end-diastolic diameter.
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.
Keywords
Humans, Uric Acid, Heart Failure, Male, Female, Middle Aged, Prospective Studies, Creatinine, Biomarkers, Prognosis, Risk Assessment, Risk Factors, Follow-Up Studies, Predictive Value of Tests, Survival Rate, Aged
Published Open-Access
yes
Recommended Citation
Xi, Xiaoqing; Cai, Jinfeng; Zhang, Chen; et al., "Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure" (2024). The Texas Heart Institute Journal. 162.
https://digitalcommons.library.tmc.edu/texasheartinstituejournal/162