Publication Date
2-1-2019
Journal
The Texas Heart Institute Journal
DOI
10.14503/THIJ-17-6408
PMID
30833832
Publication Date(s)
February 2019
Language
English
PMCID
PMC6379015
PubMedCentral® Posted Date
2-1-2019
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Adult, Arterial Switch Operation, Echocardiography, Exercise Test, Exercise Tolerance, Female, Follow-Up Studies, Heart Ventricles, Humans, Magnetic Resonance Imaging, Cine, Male, Prognosis, Retrospective Studies, Transposition of Great Vessels, Ventricular Function, Right, Young Adult
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
The right ventricle provides systemic circulation in individuals with congenitally corrected transposition of the great arteries (CCTGA) and in those with complete transposition who have had an atrial switch repair (DTGA). The aim of this study was to evaluate how the systemic right ventricle adapts to increased workload and oxygen demand during exercise. From November 2005 through December 2015, 3,358 adult patients with congenital heart disease were treated at our institution; we identified 48 (26 females, 22 males; median age, 25.4 ± 8.1 yr) who met the study criteria; 37 had DTGA and atrial switch repair, and 11 had CCTGA. We studied their echocardiographic and cardiopulmonary exercise test results. A control group consisted of 29 healthy sex- and age-matched volunteers. On exercise testing, oxygen uptake at anaerobic threshold, peak oxygen uptake, peak heart rate, and percentage of maximal heart rate were significantly lower in the group with systemic right ventricle than in the control group (all