Language
English
Publication Date
2012
Journal
The Texas Heart Institute Journal
PMID
22412222
PMCID
PMC3298915
PubMedCentral® Posted Date
2012
PubMedCentral® Full Text Version
Post-Print
Abstract
We investigated whether the expression of transforming growth factor β-1 in the left atrial appendage affected the outcome of the radiofrequency modified maze procedure in patients with rheumatic valve disease and long-standing persistent atrial fibrillation.
Messenger RNA and protein expression of transforming growth factor β-1 and volume fractions of collagen types I and III were measured in 80 patients with rheumatic valve atrial fibrillation who underwent valve surgery with the radiofrequency modified maze procedure; the same was done in a control group of 20 patients with rheumatic valve disease and sinus rhythm who underwent valve surgery alone.
At 6 months' follow-up, atrial fibrillation recurred in 24 of the 80 patients in the study group. The messenger RNA and protein expressions of transforming growth factor β-1, collagen type I volume fraction, and left atrial dimension had increased gradually in the control group and in the study subgroups that maintained sinus rhythm or relapsed into atrial fibrillation (P <0.05). The messenger RNA and protein expressions of transforming growth factor β-1 correlated positively with collagen type I volume fraction (r=0.723, P <0.001 and r=0.745, P <0.001, respectively) and left atrial dimension (r=0.762, P <0.001 and r=0.765, P <0.001, respectively). In the sinus rhythm-maintained subgroup, the patients who regained functional atrial contraction had lower messenger RNA and protein expression of transforming growth factor β-1 than did the patients who failed to retain such function (P <0.05).
We conclude that the expression of transforming growth factor β-1 in the resected left atrial appendage affects the recurrence of atrial fibrillation and restoration of functional left atrial contraction after the radiofrequency modified maze procedure.
Keywords
Atrial fibrillation/etiology/surgery, blotting, western, catheter ablation/radiofrequency/methods, collagen type I, collagen type III, fibrosis/complications, heart conduction system/physiopathology, heart valve diseases/complications, prognosis, rheumatic heart disease/complications/surgery, transforming growth factor β 1
Published Open-Access
yes
Recommended Citation
Wang, Wei; Liu, Lei; Li, Yuan; et al., "Does the Expression of Transforming Growth Factor β-1: Affect the Outcome of the Radiofrequency Modified Maze Procedure in Patients With Rheumatic Atrial Fibrillation?" (2012). The Texas Heart Institute Journal. 325.
https://digitalcommons.library.tmc.edu/texasheartinstituejournal/325