Publication Date
2012
Journal
The Texas Heart Journal
PMID
23304015
Publication Date(s)
2012
Language
English
PMCID
PMC3528235
PubMedCentral® Posted Date
2012
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Keywords
Coronary thrombosis/prevention & control/surgery, erythromelalgia, hemorrhage/drug therapy, hydroxyurea/therapeutic use, myeloproliferative disorders/genetics/pathology, polycythemia vera/blood, plateletpheresis, preoperative care/methods, risk factors, thrombocythemia, essential/complications/diagnosis/etiology/genetics/metabolism/physiopathology
Copyright
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Abstract
Extreme thrombocytosis is a major risk factor for excessive bleeding and for thrombosis, either of which can complicate cardiovascular surgical and interventional procedures. Extreme thrombocytosis can also cause an unusual syndrome, erythromelalgia, that results in a type of chronic microvascular occlusive arterial disease. We present the differential diagnosis of conditions that may lead to extreme thrombocytosis, 3 cases (each of which illustrates a different potential complication), and a review of the pertinent medical literature. Correcting excessive thrombocytosis is typically not difficult, whether electively or acutely, and effective therapy usually controls thrombosis and excessive hemorrhage post-procedurally.