Faculty, Staff and Student Publications

Language

English

Publication Date

6-1-2025

Journal

JTCVS Open

DOI

10.1016/j.xjon.2025.03.029

PMID

40631022

PMCID

PMC12230552

PubMedCentral® Posted Date

4-15-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Objective: Left ventricular assist device (LVAD) implantation is a life-saving procedure for patients with advanced heart failure. However, postimplantation complications such as driveline infections (DLIs) can significantly affect patient outcomes. We assessed whether placing an extracellular matrix (ECM) scaffold around the driveline during LVAD implantation reduces the incidence of DLIs in patients with LVADs.

Methods: This retrospective observational study included 196 consecutive patients with LVADs between January 2018 and June 2022. We compared the data of patients who received ECM implantation during LVAD implantation (ECM group, n = 69) with those who did not (control group, n = 127).

Results: During the study period, 24 of 196 (12.2%) patients with LVADs developed a DLI. Patients who underwent ECM placement exhibited a significantly lower incidence of DLIs than those in the control group (ECM 3/69 vs control 21/127; P = .012).

Conclusions: Patients who received ECM implantation at the time of LVAD implantation had a significantly lower rate of DLIs than patients who did not receive ECM around the driveline. These results suggest that ECM may be a valuable adjunctive strategy to reduce the risk of DLIs in LVAD recipients.

Keywords

LVAD, extracellular matrix, ECM, driveline infection

Published Open-Access

yes

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