Faculty, Staff and Student Publications
Language
English
Publication Date
6-1-2025
Journal
JTCVS Open
DOI
10.1016/j.xjon.2025.03.029
PMID
40631022
PMCID
PMC12230552
PubMedCentral® Posted Date
4-15-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Objective: Left ventricular assist device (LVAD) implantation is a life-saving procedure for patients with advanced heart failure. However, postimplantation complications such as driveline infections (DLIs) can significantly affect patient outcomes. We assessed whether placing an extracellular matrix (ECM) scaffold around the driveline during LVAD implantation reduces the incidence of DLIs in patients with LVADs.
Methods: This retrospective observational study included 196 consecutive patients with LVADs between January 2018 and June 2022. We compared the data of patients who received ECM implantation during LVAD implantation (ECM group, n = 69) with those who did not (control group, n = 127).
Results: During the study period, 24 of 196 (12.2%) patients with LVADs developed a DLI. Patients who underwent ECM placement exhibited a significantly lower incidence of DLIs than those in the control group (ECM 3/69 vs control 21/127; P = .012).
Conclusions: Patients who received ECM implantation at the time of LVAD implantation had a significantly lower rate of DLIs than patients who did not receive ECM around the driveline. These results suggest that ECM may be a valuable adjunctive strategy to reduce the risk of DLIs in LVAD recipients.
Keywords
LVAD, extracellular matrix, ECM, driveline infection
Published Open-Access
yes
Recommended Citation
, "Impact of Extracellular Matrix Scaffold on Driveline Infection Rate in Patients With Left Ventricular Assist Devices" (2025). Faculty, Staff and Student Publications. 147.
https://digitalcommons.library.tmc.edu/uthdb_docs/147