Journal Articles

Publication Date



Frontiers in Immunology


Failure of resolution pathways in periodontitis is reflected in levels of specialized pro-resolving lipid mediators (SPMs) and SPM pathway markers but their relationship with the subgingival microbiome is unclear. This study aimed to analyze and integrate lipid mediator level, SPM receptor gene expression and subgingival microbiome data in subjects with periodontitis vs. healthy controls. The study included 13 periodontally healthy and 15 periodontitis subjects that were evaluated prior to or after non-surgical periodontal therapy. Samples of gingival tissue and subgingival plaque were collected prior to and 8 weeks after non-surgical treatment; only once in the healthy group. Metabololipidomic analysis was performed to measure levels of SPMs and other relevant lipid mediators in gingiva. qRT-PCR assessed relative gene expression (2


Adaptor Proteins, Signal Transducing, Adult, Bacteria, Female, Gingiva, Humans, Lipid Metabolism, Lipids, Male, Metabolome, Microbiota, Middle Aged, Periodontitis, RNA, Ribosomal, 16S, Receptors, Chemokine, Receptors, G-Protein-Coupled, Receptors, Leukotriene B4, Young Adult

Included in

Dentistry Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.