Faculty, Staff and Student Publications

Publication Date

1-1-2021

Journal

Frontiers in Immunology

Abstract

Failure of resolution pathways in periodontitis is reflected in levels of specialized pro-resolving lipid mediators (SPMs) and SPM pathway markers but their relationship with the subgingival microbiome is unclear. This study aimed to analyze and integrate lipid mediator level, SPM receptor gene expression and subgingival microbiome data in subjects with periodontitis vs. healthy controls. The study included 13 periodontally healthy and 15 periodontitis subjects that were evaluated prior to or after non-surgical periodontal therapy. Samples of gingival tissue and subgingival plaque were collected prior to and 8 weeks after non-surgical treatment; only once in the healthy group. Metabololipidomic analysis was performed to measure levels of SPMs and other relevant lipid mediators in gingiva. qRT-PCR assessed relative gene expression (2

Keywords

Adaptor Proteins, Signal Transducing, Adult, Bacteria, Female, Gingiva, Humans, Lipid Metabolism, Lipids, Male, Metabolome, Microbiota, Middle Aged, Periodontitis, RNA, Ribosomal, 16S, Receptors, Chemokine, Receptors, G-Protein-Coupled, Receptors, Leukotriene B4, Young Adult

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