Student and Faculty Publications
Publication Date
7-1-2019
Journal
Oral Diseases
Abstract
OBJECTIVES: Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients.
MATERIALS AND METHODS: A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response.
RESULTS: Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs.
CONCLUSION: In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.
Keywords
Dietary Supplements, Humans, Inflammation, Inflammation Mediators, Periodontitis, Pilot Projects, Vitamin D, Vitamin D Deficiency, Vitamins
Recommended Citation
Meghil, Mohamed M; Hutchens, Lance; Raed, Anas; Multani, Neha A; Rajendran, Mythilypriya; Zhu, Haidong; Looney, Stephen; Elashiry, Mahmoud; Arce, Roger M; Peacock, Mark E; Dong, Yanbin; and Cutler, Christopher W, "The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study" (2019). Student and Faculty Publications. 39.
https://digitalcommons.library.tmc.edu/uthdb_docs/39