Disruption of Immune Homeostasis In Human Dendritic Cells Via Regulation of Autophagy and Apoptosis By Porphyromonas gingivalis

Authors

Mohamed M Meghil
Omnia K Tawfik
Mahmoud Elashiry
Mythilypriya Rajendran
Roger M Arce
David J Fulton
Patricia V Schoenlein
Christopher W Cutler

Publication Date

1-1-2019

Journal

Frontiers in Immunology

Abstract

As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, and dysregulation of dendritic cell (DC) and T cell responses. The aim of this study was to elucidate the underlying mechanisms by which the oral microbe

Keywords

Apoptosis, Autophagy, Bacteroidaceae Infections, Cells, Cultured, Dendritic Cells, Fimbriae, Bacterial, Forkhead Box Protein O1, Homeostasis, Humans, Porphyromonas gingivalis, Proto-Oncogene Proteins c-akt, Toll-Like Receptor 1, Toll-Like Receptor 2

DOI

10.3389/fimmu.2019.02286

PMID

31608069

PMCID

PMC6769118

PubMedCentral® Posted Date

September 2019

PubMedCentral® Full Text Version

Post-print

Recommended Citation

Meghil, Mohamed M; Tawfik, Omnia K; Elashiry, Mahmoud; Rajendran, Mythilypriya; Arce, Roger M; Fulton, David J; Schoenlein, Patricia V; and Cutler, Christopher W, "Disruption of Immune Homeostasis In Human Dendritic Cells Via Regulation of Autophagy and Apoptosis By Porphyromonas gingivalis" (2019). Faculty, Staff and Student Publications. 40.
https://digitalcommons.library.tmc.edu/uthdb_docs/40